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Recombinant MSH6 Antibody

CAT: 0800-V8634-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V8634-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P52701
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 374-540 from the human protein was used as the immunogen for the recombinant MSH6 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2a κ
Clone
RMSH6/4743
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant MSH6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant MSH6 antibody is available for research use only.
Storage Conditions
Store the recombinant MSH6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant MSH6 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human colon carcinoma with recombinant MSH6 antibody (clone rMSH6/4743) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P52701

DNA mismatch repair protein Msh6

MSH6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52701
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MSH6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hMSH6
EC number
—
Processing
—
Secondary accessions
B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

ChromosomeNucleus

Disease

Disease variantHereditary nonpolyposis colorectal cancer

Biological process

DNA damageDNA repairHost-virus interaction

Molecular function

DNA-binding

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