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Recombinant PSA Antibody / Prostate Specific Antigen

CAT: 0800-V8460-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V8460-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a single protein of 33-34kDa, identified as the prostate specific antigen (PSA) . This MAb is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT) . A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. This mAb makes an excellent pair with clone 1A7G6B6 for PSA tests.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P07288
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant full-length human KLK3/PSA protein was used as the immunogen for the recombinant PSA antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
KLK3/4551R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant PSA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant PSA antibody is available for research use only.
Storage Conditions
Store the recombinant PSA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant PSA antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human prostate carcinoma with recombinant PSA antibody (clone KLK3/4551R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P07288

Prostate-specific antigen

KLK3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07288
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KLK3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PSA
EC number
3.4.21.77
Processing
Precursor
Secondary accessions
C9JXH3, G3V0H4, G3XAE3, Q15096, Q16272, Q86TG8, Q8IXI4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

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