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Aciculin Antibody / PGM5 / Phosphoglucomutase 5

CAT: 0800-V8411-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8411-100UGSize:100 µg
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Description
Aciculin, also known as PGM5 (phosphoglucomutase 5) or PGMRP, is a 567 amino acid protein that belongs to the phosphoglucomutase family of phosphotransferases, which play an important role in the interconversion of glucose-1-phosphate and glucose-6-phosphate. Localized to the cell junction and expressed at high levels in smooth and cardiac muscle, Aciculin binds magnesium as a cofactor and interacts with dystrophin and utrophin, possibly playing a role in cytoskeletal organization and function. Aciculin exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q15124
Host
Mouse
Reactivity
Human
Immunogen
The cytoskeletal fraction of the human myometrium tissue extract was used as the immunogen for the Aciculin antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
14F8/F8
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Aciculin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Aciculin antibody is available for research use only.
Storage Conditions
Store the Aciculin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Aciculin antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human uterus with Aciculin antibody (clone 14F8/F8) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q15124

Phosphoglucomutase-like protein 5

PGM5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15124
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PGM5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B1AM46, B4DLQ6, Q5VYV3, Q8N527, Q9UDH4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembrane

PTM

Phosphoprotein

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