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Recombinant Thyroid Peroxidase Antibody

CAT: 0800-V8137-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8137-100UGSize:100 µg
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Description
Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P07202
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 685-804) was used as the immunogen for this TPO antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TPO/3813R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the recombinant Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Thyroid Peroxidase antibody is available for research use only.
Storage Conditions
Store the recombinant Thyroid Peroxidase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant Thyroid Peroxidase antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human thyroid carcinoma with recombinant Thyroid Peroxidase antibody (clone TPO/3813R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P07202

Thyroid peroxidase

PERT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07202
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TPO
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TPO
EC number
1.11.1.8
Processing
Precursor
Secondary accessions
P09934, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumHemeIronMetal-binding

Disease

Congenital hypothyroidismDisease variant

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainSignalSushiTransmembraneTransmembrane helix

Biological process

Hydrogen peroxideThyroid hormones biosynthesis

Cellular component

Membrane

Molecular function

OxidoreductasePeroxidase

Technical term

Proteomics identificationReference proteome
Product Datasheet
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