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Recombinant Thyroid Peroxidase Antibody

CAT: 0013-GTR18575003Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18575003Size:100 µg
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Description
Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
UniProt
P07202
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 685-804) was used as the immunogen for this TPO antibody.
Clonality
Recombinant
Clone
TPO/3813R
Conjugation
Unconjugated
Purification
Protein A affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant Thyroid Peroxidase antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Rabbit IgG, kappa

UniProtKB · P07202

Thyroid peroxidase

PERT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07202
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TPO
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TPO
EC number
1.11.1.8
Processing
Precursor
Secondary accessions
P09934, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumHemeIronMetal-binding

Disease

Congenital hypothyroidismDisease variant

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainSignalSushiTransmembraneTransmembrane helix

Biological process

Hydrogen peroxideThyroid hormones biosynthesis

Cellular component

Membrane

Molecular function

OxidoreductasePeroxidase

Technical term

Proteomics identificationReference proteome

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