TIMP1 Antibody

CAT: 0800-V8117SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V8117SAF-100UGSize:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity) . PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
P01033
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 72-82 (FQALGDAADIR) were used as the immunogen for this TIMP1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
2A5
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the TIMP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TIMP1 antibody is available for research use only.
Storage Conditions
Store the TIMP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the TIMP1 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free TIMP1 antibody (clone 2A5) as confirmation of integrity and purity.

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