Recombinant CD137 Antibody / 4-1BB / TNFRSF9

• Description:

  CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Western blot: 2-4 µg/mL

• UniProt:

  Q07011

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A human CD137 protein fragment within amino acids 19-188 was used as the immunogen for the recombinant CD137 antibody.

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG κ

• Clone:

  4-1BB/4552R

• Type:

  Recombinant

• Applications:

  IHC-P, WB

• Purity:

  Protein A affinity chromatography

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Reconstitution:

  Store the recombinant CD137 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This recombinant CD137 antibody is available for research use only.

• Storage Conditions:

  Store the recombinant CD137 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

• Applications Notes:

  Optimal dilution of the recombinant CD137 antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Location:

  Cell surface, cytoplasmic

• Image Legend:

  IHC staining of FFPE human kidney with CD137 antibody (clone 4-1BB/4552R) . HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.