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CD45 Antibody Cocktail

CAT: 0800-V8042-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8042-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P08575
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant full-length CD45 protein was used as the immunogen for the CD45 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PTPRC/1147 + PTPRC/1460
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD45 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD45 antibody is available for research use only.
Storage Conditions
Store the CD45 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD45 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human tonsil with CD45 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · P08575

Receptor-type tyrosine-protein phosphatase C

PTPRC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08575
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPRC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
Precursor
Secondary accessions
A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSynapse

Disease

Disease variantSCID

PTM

GlycoproteinPhosphoprotein

Biological process

Host-virus interaction

Molecular function

HydrolaseProtein phosphatase

Domain

RepeatSignalTransmembraneTransmembrane helix

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