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ORC1 Antibody / Origin Recognition Complex 1

CAT: 0800-V7992-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7992-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
Q13415
Host
Mouse
Reactivity
Human
Immunogen
A recombinant full-length human ORC1 protein was used as the immunogen for this ORC1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
7F6/1
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the ORC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This ORC1 antibody is available for research use only.
Storage Conditions
Store the ORC1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the ORC1 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free ORC1 antibody (clone 7F6/1) as confirmation of integrity and purity.
Product Datasheet
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Alternative Products

CatalogName
376648ORC1 (Origin Recognition Complex) discontinued
326952-01Origin recognition complex subunit 4
487807ORC2 (Origin Recognition Complex Subunit 2 Ensembl ENSMUSP00000109964, Origin Recognition Complex, Subunit 2)
130738ORC3L (Origin Recognition Complex Subunit 3, Origin Recognition Complex Subunit Latheo, ORC3, LATHEO)
O7050-27CORC6L (Origin Recognition Complex Subunit 6-like, Origin Recognition Complex Subunit 6 Homolog-like (yeast), Origin Recognition Complex Subunit 6 Homolog-like 2, Origin Recognition Complex Subunit 6, ORC6)
130745-HRPORC6L (Origin Recognition Complex Subunit 6-like, Origin Recognition Complex Subunit 6 Homolog-like (yeast), Origin Recognition Complex Subunit 6 Homolog-like 2, Origin Recognition Complex Subunit 6, ORC6) (HRP)
130745-PEORC6L (Origin Recognition Complex Subunit 6-like, Origin Recognition Complex Subunit 6 Homolog-like (yeast), Origin Recognition Complex Subunit 6 Homolog-like 2, Origin Recognition Complex Subunit 6, ORC6) (PE)
130745-APCORC6L (Origin Recognition Complex Subunit 6-like, Origin Recognition Complex Subunit 6 Homolog-like (yeast), Origin Recognition Complex Subunit 6 Homolog-like 2, Origin Recognition Complex Subunit 6, ORC6) (APC)
MBS6148625-01ORC6L (Origin Recognition Complex Subunit 6-like, Origin Recognition Complex Subunit 6 Homolog-like (yeast), Origin Recognition Complex Subunit 6 Homolog-like 2, Origin Recognition Complex Subunit 6, ORC6) (FITC)
130744-BiotinORC6L (Origin Recognition Complex Subunit 6-like, Origin Recognition Complex Subunit 6 Homolog-like (yeast), Origin Recognition Complex Subunit 6 Homolog-like 2, Origin Recognition Complex Subunit 6, ORC6) (Biotin)

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