MSH2 Antibody

MSH2 Antibody

• Description: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
• CAS Number: 9007-83-4
• UniProt: P43246
• Host: Mouse
• Immunogen: A recombinant human partial protein (amino acids 327-427) was used as the immunogen for this MSH2 antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: FACS, IF, WB, IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Store the MSH2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This MSH2 antibody is available for research use only.