CD117 Antibody / c-Kit

CAT: 0800-V7906-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V7906-20UGSize:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This MAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
P10721
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full length protein was used as the immunogen for the CD117 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
KIT/2669
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD117 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD117 antibody is available for research use only.
Storage Conditions
Store the CD117 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD117 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using CD117 antibody (clone KIT/2669) . These results demonstrate the foremost specificity of the KIT/2669 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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