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CD35 Antibody / CR1

CAT: 0800-V7691SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7691SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1) /CD35. This MAb does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein.Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, , Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P17927
Host
Mouse
Reactivity
Human
Immunogen
Follicular dendritic cells (FDC) from the tonsil were used as the immunogen for the CD35 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
To5
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CD35 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD35 antibody is available for research use only.
Storage Conditions
Store the CD35 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CD35 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
IHC staining of FFPE human tonsil with CD35 antibody (clone To5) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · P17927

Complement receptor type 1

CR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17927
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q16744, Q16745, Q5SR43, Q5SR45, Q9UQV2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Blood group antigenHost cell receptor for virus entryReceptor

Biological process

Complement pathwayHost-virus interactionImmunityInnate immunity

PTM

Disulfide bondGlycoproteinPyrrolidone carboxylic acid

Cellular component

Membrane

Domain

RepeatSignalSushiTransmembraneTransmembrane helix

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