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TIM3 Antibody / HAVCR2

CAT: 0800-V7582IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7582IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2) . In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q8TDQ0
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human TIM3 protein within amino acids 22-202 was used as the immunogen for the TIM3 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
TIM3/3113
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the TIM3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TIM3 antibody is available for research use only.
Storage Conditions
Store the TIM3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human adrenal gland with TIM3 antibody (clone TIM3/3113) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · Q8TDQ0

Hepatitis A virus cellular receptor 2

HAVR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TDQ0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HAVCR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HAVcr-2
EC number
—
Processing
Precursor
Secondary accessions
B2RAY2, Q8WW60, Q96K94
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInflammatory responseInnate immunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Ligand

Metal-binding

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