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TIM3 Antibody / HAVCR2

CAT: 0800-V7533SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7533SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by the HAVCR2 gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [RefSeq]
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
Q8TDQ0
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human TIM3 protein within amino acids 22-202 was used as the immunogen for the TIM3 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
TMDP3-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the TIM3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TIM3 antibody is available for research use only.
Storage Conditions
Store the TIM3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human adrenal gland with TIM3 antibody (clone TMDP3-1) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · Q8TDQ0

Hepatitis A virus cellular receptor 2

HAVR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TDQ0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HAVCR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HAVcr-2
EC number
—
Processing
Precursor
Secondary accessions
B2RAY2, Q8WW60, Q96K94
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInflammatory responseInnate immunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Ligand

Metal-binding

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