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Sarcomeric Alpha Actinin Antibody / ACTN2

CAT: 0800-V7529IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7529IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P35609
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 557-692 from the human protein were used as the immunogen for this Sarcomeric Alpha Actinin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ACTN2/3292
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Sarcomeric Alpha Actinin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Sarcomeric Alpha Actinin antibody is available for research use only.
Storage Conditions
Store the Sarcomeric Alpha Actinin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human skeletal muscle tissue with Sarcomeric Alpha Actinin antibody (clone ACTN2/3292) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · P35609

Alpha-actinin-2

ACTN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35609
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACTN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B1ANE4, B2RCS5, Q86TF4, Q86TI8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-binding

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Disease

CardiomyopathyDisease variant

Cellular component

Cytoplasm

PTM

PhosphoproteinUbl conjugation

Domain

Repeat

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