ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin

ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin

• Description: Alpha-actinin 2 is a protein which in humans is encoded by the ACTN2 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
• CAS Number: 9007-83-4
• UniProt: P35609
• Host: Rabbit
• Immunogen: An E. coli-derived human protein (amino acids E567-E696) was used as the immunogen for the ACTN2 antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, IHC-P, FACS, Direct ELISA
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the ACTN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This ACTN2 antibody is available for research use only.