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Sarcomeric Alpha Actinin Antibody / ACTN2

CAT: 0800-V7529-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7529-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P35609
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 557-692 from the human protein were used as the immunogen for this Sarcomeric Alpha Actinin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ACTN2/3292
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.05% sodium azide
Reconstitution
Store the Sarcomeric Alpha Actinin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Sarcomeric Alpha Actinin antibody is available for research use only.
Storage Conditions
Store the Sarcomeric Alpha Actinin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human skeletal muscle tissue with Sarcomeric Alpha Actinin antibody (clone ACTN2/3292) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · P35609

Alpha-actinin-2

ACTN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35609
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACTN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B1ANE4, B2RCS5, Q86TF4, Q86TI8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-binding

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Disease

CardiomyopathyDisease variant

Cellular component

Cytoplasm

PTM

PhosphoproteinUbl conjugation

Domain

Repeat

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