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FOLH1 Antibody / PSMA

CAT: 0800-V7505IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7505IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q04609
Host
Mouse
Reactivity
Human, Rat, Dog, Cow
Immunogen
A portion of amino acids 232-433 from the human protein was used as the immunogen for this FOLH1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
FOLH1/2363
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the FOLH1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FOLH1 antibody is available for research use only.
Storage Conditions
Store the FOLH1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic, cell surface
Image Legend
IHC testing of FFPE human prostate cancer with FOLH1 antibody. Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · Q04609

Glutamate carboxypeptidase 2

FOLH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04609
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FOLH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.17.21
Processing
—
Secondary accessions
A4UU12, A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8, O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, Q9NYE2, Q9P1P8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

Molecular function

CarboxypeptidaseDipeptidaseHydrolaseMetalloproteaseMultifunctional enzymeProtease

Cellular component

Cell membraneCytoplasmMembrane

PTM

GlycoproteinPhosphoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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