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GATA3 Antibody

CAT: 0800-V7481-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7481-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GATA3 is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. GATA3 expression is primarily seen in breast and urothelial carcinomas. Therefore, GATA3 antibody can be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Flow cytometry: 1-2ug/10^6 cells, Western blot: 0.5-1 µg/mL
UniProt
P23771
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 357-463 from the human protein were used as the immunogen for this GATA3 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
GATA3/2446
Applications
ELISA, FACS, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the GATA3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This GATA3 antibody is available for research use only.
Storage Conditions
Store the GATA3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear
Image Legend
IHC testing of FFPE human breast carcinoma with GATA3 antibody. Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min and allow to cool prior to testing.

UniProtKB · P23771

Trans-acting T-cell-specific transcription factor GATA-3

GATA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23771
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GATA3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5VWG7, Q5VWG8, Q96J16
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Disease

DeafnessDisease variant

Biological process

ImmunityInnate immunityTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

PTM

Phosphoprotein

Domain

RepeatZinc-finger

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