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AMACR Antibody / p504S

CAT: 0800-V7479IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7479IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody recognizes a protein of 43kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells) . Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium) . AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q9UHK6
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 297-394 was used as the immunogen for the AMACR antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
AMACR/1864
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the AMACR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This AMACR antibody is available for research use only.
Storage Conditions
Store the AMACR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human renal carcinoma with AMACR antibody. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

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