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Ki67 Antibody

CAT: 0800-V7435IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7435IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki67 index and the histo-pathological grade of neoplasms. Assessment of Ki67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki67 is a good marker of proliferating cell populations.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P46013
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 2293-2478 was used as the immunogen for the Ki67 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MKI67/2463
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Ki67 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Ki67 antibody is available for research use only.
Storage Conditions
Store the Ki67 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear
Image Legend
IHC testing of FFPE human tonsil stained with Ki67 antibody (MKI67/2463) . Required HIER: boiling tissue sections in 10mM citrate buffer, pH6, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P46013

Proliferation marker protein Ki-67

KI67_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46013
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MKI67
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5VWH2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycle

Cellular component

ChromosomeNucleus

Molecular function

DNA-binding

Domain

Repeat

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