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Recombinant CD45RB Antibody

CAT: 0800-V7331-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7331-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out) . The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin. This antigen is also expressed on the surface of cells of myeloid lineage.
CAS Number
9000-83-3
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08575
Host
Rabbit
Reactivity
Human
Immunogen
Full length recombinant human protein was used as immunogen for this recombinant CD45RB antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
PTPRC/2877R
Type
Recombinant
Applications
FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
The recombinant CD45RB antibody (with azide) can be stored at 2-8oC. The azide-free format should be aliquoted and stored at -20oC or colder.
Limitations
This recombinant CD45RB antibody is available for research use only.
Storage Conditions
The recombinant CD45RB antibody (with azide) can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface and cytoplasmic
Image Legend
Western blot testing of recombinant CD45RB antibody and human Raji lysate. Expected molecular weight: 147-220 kDa depending on glycosylation level.

UniProtKB · P08575

Receptor-type tyrosine-protein phosphatase C

PTPRC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08575
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPRC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
Precursor
Secondary accessions
A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSynapse

Disease

Disease variantSCID

PTM

GlycoproteinPhosphoprotein

Biological process

Host-virus interaction

Molecular function

HydrolaseProtein phosphatase

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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