Products for Research Use Only
RegisterLogin

Recombinant DOG1 Antibody

CAT: 0800-V7326SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V7326SAF-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q5XXA6
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 2-101 from the human protein was used as the immunogen for this recombinant DOG1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
DG1/2564R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant DOG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant DOG1 antibody is available for research use only.
Storage Conditions
Store the recombinant DOG1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cell Surface and Cytoplasmic
Image Legend
IHC testing of FFPE human gastrointestinal stromal tumor (GIST) with DOG1 antibody (clone DG1/2564R) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q5XXA6

Anoctamin-1

ANO1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5XXA6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ANO1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A2H4Y9B2, A8KAM3, E9PNA7, Q8IYY8, Q8N7V3
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumChlorideMetal-binding

Cellular component

Cell membraneCell projectionMembraneSynapse

Molecular function

Chloride channelDevelopmental proteinIon channel

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Ion transportTransport

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix
Product Datasheet
Loading...

Related Products

CatalogName
V7053SAF-100UGDOG1 Antibody
F46427-0.4MLDOG1 Antibody
V3473IHC-7MLDOG1 Antibody
F46427-0.08MLDOG1 Antibody
V3334-20UGDOG1 Antibody
V7053IHC-7MLDOG1 Antibody
V7053-20UGDOG1 Antibody
V3334-100UGDOG1 Antibody
V3473-20UGDOG1 Antibody
V7053-100UGDOG1 Antibody

Alternative Products

CatalogName
GTR18574375Recombinant DOG1 Antibody
GTR18573476Recombinant ANO1 Antibody / DOG1 / TMEM16A
GTR18082624-01Recombinant TMEM16A Antibody / DOG1 / ANO1
MBS566836-01DOG1 Recombinant monoclonal antibody (DG1/1487R)
PHY0769ADOG1 Antibody
MBS2580002-01DOG1 Monoclonal Antibody
HAR334-6mlDOG1

Popular Products