CD146 Antibody / MCAM / MUC18

• Description:

  CD146/MUC18/MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [UniProt]

• UniProt:

  P43121

• Host:

  Mouse

• Immunogen:

  Recombinant human protein was used as the immunogen for the CD146 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Reconstitution:

  Store the CD146 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This CD146 antibody is available for research use only.

• CAS Number:

  9007-83-4