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Estrogen Receptor beta Antibody

CAT: 0800-V7059-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7059-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including alpha and beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER alpha and beta are differentially activated by various ligands. Ligand interaction triggers a cascade of events, including dissociation from heat shock proteins, recepter dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER alpha and beta may be regulated by distinct mechanisms even though they share many functional characteristics.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10e6 cells, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT (1), Prediluted IHC only format: incubate for 30 min at RT (2)
Host
Mouse
Reactivity
Human
Immunogen
The C-terminus fragment of recombinant human Estrogen Receptor beta protein was used as the immunogen for this antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
NR3Gb-1
Applications
WB, IHC, FACS
Purity
Protein G purified
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Estrogen receptor beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Estrogen Receptor beta antibody is available for research use only.
Storage Conditions
Store the Estrogen receptor beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Predominantly nuclear
Image Legend
IHC testing of ovarian cancer stained with Estrogen Receptor beta antibody (clone NR3Gb-1) .
Product Datasheet
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