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Cyclin D1 Antibody

CAT: 0800-V7043SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7043SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
CAS Number
9007-83-4
Specifications
Flow Cytometry: 0.5-1ug/million cells in 0.1ml, Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT (1), Prediluted IHC only format: incubate for 30 min at RT (2)
UniProt
P24385
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the Cyclin D1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
BCLD1-1
Applications
FACS, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Cyclin D1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cyclin D1 antibody is available for research use only.
Storage Conditions
Store the Cyclin D1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Nuclear
Image Legend
IHC testing of human mantle cell lymphoma and Cyclin D1 antibody (clone BCLD1-1) .
Product Datasheet
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