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AMACR Antibody

CAT: 0800-V3990IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V3990IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The AMACR gene encodes the racemase Alpha-methylacyl-CoA. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [RefSeq]
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q9UHK6
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 297-394 was used as the immunogen for the AMACR antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
2MACR-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the AMACR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This AMACR antibody is available for research use only.
Storage Conditions
Store the AMACR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human prostate carcinoma with AMACR antibody (clone 2MACR-1) . Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

UniProtKB · Q9UHK6

Alpha-methylacyl-CoA racemase

AMACR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UHK6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AMACR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
5.1.99.4
Processing
—
Secondary accessions
A5YM47, B8Y916, B8Y918, F8W9N1, O43673, Q3KT79, Q96GH1, Q9Y3Q1
Protein keywords

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Disease

Disease variantIntrahepatic cholestasis

Molecular function

Isomerase

Cellular component

MitochondrionPeroxisome

Technical term

Proteomics identificationReference proteome
Product Datasheet
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