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Mesothelin Antibody / MSLN

CAT: 0800-V3820-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3820-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Western blot: 2-4 µg/mL
UniProt
Q13421
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 273-407 from the human protein was used as the immunogen for this Mesothelin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MSLN/2131
Applications
IHC-P, WB
Purity
Protein G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
After reconstitution, the Mesothelin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Mesothelin antibody is available for research use only.
Storage Conditions
After reconstitution, the Mesothelin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the MSLN antibody should be determined by the researcher.
Location
Cytoplasmic, cell surface, secreted
Image Legend
IHC testing of FFPE human lung mesothelioma with Mesothelin antibody (clone MSLN/2131) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q13421

Mesothelin

MSLN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13421
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MSLN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DU65, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneGolgi apparatusMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinGPI-anchorLipoproteinPhosphoprotein

Domain

Signal
Product Datasheet
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