CD44v3 Antibody

CAT: 0800-V3769-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V3769-20UGSize:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. It is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P16070
Host
Mouse
Reactivity
Human
Immunogen
An amino acid sequence from the variant 3 domain of CD44 was used as the immunogen for the CD44v3 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CDLA44v3-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD44v3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD44v3 antibody is available for research use only.
Storage Conditions
Store the CD44v3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the CD44v3 antibody may be required for optimal performance.
Location
Cell surface, cytoplasmic
Image Legend
IHC testing of FFPE human prostate carcinoma with CD44v3 antibody (clone CDLA44v3-1) . Required HIER: steam sections in pH6 citrate buffer for 10-20 min and allow to cool before testing.

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