Products for Research Use Only
RegisterLogin

Recombinant SOX10 Antibody

CAT: 0800-V3690IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V3690IHC-7MLSize:7 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
CAS Number
9000-83-3
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P56693
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 115-269 of the human protein were used as the immunogen for the recombinant SOX10 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
SOX10/2311R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant SOX10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant SOX10 antibody is available for research use only.
Storage Conditions
Store the recombinant SOX10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear
Image Legend
IHC testing of FFPE melanoma with recombinant SOX10 antibody (clone SOX10/2311R) . Required HIER: boil sections in pH 9 10mM Tris with 1mM EDTA for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining.

UniProtKB · P56693

Transcription factor SOX-10

SOX10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56693
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOX10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DV62, Q6FHW7
Protein keywords

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membraneNucleus

Disease

DeafnessDisease variantHirschsprung diseaseKallmann syndromeWaardenburg syndrome

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation

Related Products

CatalogName
V8813SAF-100UGSOX10 Antibody
V3508-100UGSOX10 Antibody
V8813-20UGSOX10 Antibody
V8947-100UGSOX10 Antibody
RQ8265SOX10 Antibody
V8813-100UGSOX10 Antibody
V3507-20UGSOX10 Antibody
V3507SAF-100UGSOX10 Antibody
V8947-20UGSOX10 Antibody
F49359-0.08MLSOX10 Antibody

Alternative Products

CatalogName
RC-4468-01Recombinant SOX10 Antibody
bsm-52229R-01SOX10 Recombinant Antibody
CSB-RA592917A0HU-01SOX10 Recombinant Monoclonal Antibody
AE00288SOX10 Recombinant Antibody AE00288
AE00289SOX10 Recombinant Antibody AE00289
AN300714L-01Recombinant SOX10 Monoclonal Antibody
HA601413SOX10 Recombinant Chimeric Antibody Antibody
GTR18711695SOX10 Recombinant Rabbit mAb Antibody
bsm-52229R-Cy7SOX10 Recombinant Antibody, Cy7 Conjugated
bsm-52229R-BiotinSOX10 Recombinant Antibody, Biotin Conjugated

Popular Products