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Recombinant SOX10 Antibody

CAT: 0800-V3563IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V3563IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb recognizes a protein of ~50 kDa identified as SOX10. This mAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX10 is moderately to strongly expressed in desmoplastic melanomas. SOX10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX10 expression is also observed in mast cells.
CAS Number
9000-83-3
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P56693
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Amino acids 115-269 from the human protein were used as the immunogen for the recombinant SOX10 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RSOX10/1074
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant SOX10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant SOX10 antibody is available for research use only.
Storage Conditions
Store the recombinant SOX10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear
Image Legend
IHC testing of FFPE human melanoma with recombinant SOX10 antibody (clone rSOX10/1074) . Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P56693

Transcription factor SOX-10

SOX10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56693
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOX10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DV62, Q6FHW7
Protein keywords

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membraneNucleus

Disease

DeafnessDisease variantHirschsprung diseaseKallmann syndromeWaardenburg syndrome

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation

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