Products for Research Use Only
RegisterLogin

SOX18 Antibody

CAT: 0800-V4834-20UGSize: 20 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V4834-20UGSize:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNAbinding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-18 is a 384 amino acid nuclear protein that contains one HMG box DNA-binding domain and belongs to the Sox family of transcriptional regulators.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P35713
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human SOX18 protein fragment (within amino acids 50-250) was used as the immunogen for the SOX18 antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
SOX18/3271
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the SOX18 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SOX18 antibody is available for research use only.
Storage Conditions
Aliquot the SOX18 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the SOX18 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human skin tissue with SOX18 antibody (clone SOX18/3271) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P35713

Transcription factor SOX-18

SOX18_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35713
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOX18
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q0VGA9, Q9NPH8
Protein keywords

Molecular function

ActivatorDNA-binding

Disease

Disease variantHypotrichosis

Cellular component

Nucleus

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation

Related Products

CatalogName
RZ1116Zebrafish Sox1 Antibody / Sox1a / Sox1b
F53214-0.08MLSox17 Antibody
V8813SAF-100UGSOX10 Antibody
V3508-100UGSOX10 Antibody
F52988-0.4MLSox17 Antibody
RQ6577Sox11 Antibody
F52803-0.4MLSox17 Antibody
F44542-0.08MLSOX11 Antibody
V8813-20UGSOX10 Antibody
R36049-100UGSOX11 Antibody

Alternative Products

CatalogName
GWB-632F79SOX18 Antibody

Popular Products