RegisterLogin

FOXA1 Antibody

CAT: 0800-V3453-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V3453-20UGSize:20 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
The transcription factor Forkhead-box A1, also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. Its expression correlates with estrogen receptor (ER) -positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT, Western blot: 1-2 µg/mL, Immunofluorescence: 2-4 µg/mL, Flow cytometry: 1-2ug/million cells
UniProt
P55317
Host
Mouse
Reactivity
Human, Rat
Immunogen
A human recombinant partial protein corresponding to amin acids 372-472 was used as the immunogen for this FOXA1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
FOXA1/1241
Applications
IHC-P, WB, FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the FOXA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FOXA1 antibody is available for research use only.
Storage Conditions
Store the FOXA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FOXA1 antibody to be titered up or down for optimal performance.
Location
Nuclear
Image Legend
Immunofluorescent staining of PFA-fixed human MCF7 cells with FOXA1 antibody (clone FOXA1/1241, green) and Reddot (red) .
Product Datasheet
Loading...

Related Products

CatalogName
F42808-0.08MLFOXA2 Antibody
R20418-0.1MLFOXP1 Antibody
F42808-0.4MLFOXA2 Antibody
F41217-0.4MLFOXA2 Antibody
R33201-100UGFOXE1 Antibody
V9554-100UGFOXL1 Antibody
F51920-0.08MLFOXG1 Antibody
F41870-0.08MLFOXA2 Antibody
F51920-0.4MLFOXG1 Antibody
V9506-100UGFOXP1 Antibody

Alternative Products

CatalogName
33-660FOXA1 Antibody [FOXA1/1514]
33-728FOXA1 Antibody [FOXA1/1519]
33-798FOXA1 Antibody [FOXA1/1241]
33-659FOXA1 Antibody [FOXA1/1512]
33-699FOXA1 Antibody [FOXA1/1515]
33-729FOXA1 Antibody [FOXA1/1518]
MBS7117552-01FOXA1 Antibody

Popular Products