CD44v6 Antibody

• Description:

  This antibody recognizes an epitope encoded by exon v6 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

• UniProt:

  P16070

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  An amino acid sequence from the variant 6 domain of CD44 was used as the immunogen for the CD44v6 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Clone:

  CD44v6/1246

• Applications:

  IHC-P

• Purity:

  Protein G affinity chromatography

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Store the CD44v6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This CD44v6 antibody is available for research use only.

• Storage Conditions:

  Store the CD44v6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  Titering of the CD44v6 antibody may be required for optimal performance.

• CAS Number:

  9007-83-4

• Location:

  Cell surface, cytoplasmic

• Image Legend:

  IHC testing of FFPE human tongue carcinoma with CD44v6 antibody (clone CD44v6/1246) . Required HIER: steam sections in pH 9 10mM Tris with 1mM EDTA buffer for 10-20 min.