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CD1a Antibody

CAT: 0800-V3253-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3253-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa) .
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
P06126
Host
Rabbit
Reactivity
Human
Immunogen
Human CD1a protein was used as the immunogen for this CD1a antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the CD1a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD1a antibody is available for research use only.
Storage Conditions
Store the CD1a antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD1a antibody to be titered up or down for optimal performance.
Location
Cell surface, cytoplasmic
Image Legend
IHC testing of FFPE human skin with CD1a antibody. Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.
Product Datasheet
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