BRCA1 Antibody

CAT: 0800-V3239SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V3239SAF-100UGSize:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) . This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL for coating (order BSA/sodium azide-free format)
UniProt
P38398
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
BRCA1/1472
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the BRCA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This BRCA1 antibody is available for research use only.
Storage Conditions
Store the BRCA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the BRCA1 antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic

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