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IFN gamma Antibody

CAT: 0800-V3193SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3193SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 20-25kDa, identified as human interferon. This mAb is specific to human IFNg and recognizes both recombinant and native human IFNg. T lymphocytes and NK cells mainly produce IFNg. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak anti-viral and anti-proliferative activity, and potentiates the antiviral and anti-tumor effects of IFNa/b (type I interferon) .
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01579
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant protein was used as the immunogen for the IFN gamma antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
IFNG/466
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the IFN gamma antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This IFN gamma antibody is available for research use only.
Storage Conditions
Store the IFN gamma antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the IFN gamma antibody should be determined by the researcher.
Location
Cytoplasmic, membranous, extracellular (secreted)
Image Legend
IHC testing of FFPE human renal cell carcinoma with IFN gamma antibody (clone IFNG/466) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.

UniProtKB · P01579

Interferon gamma

IFNG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01579
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IFNG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IFN-gamma
EC number
—
Processing
Precursor
Secondary accessions
B5BU88, Q53ZV4
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Biological process

Antiviral defenseGrowth regulation

PTM

Cleavage on pair of basic residuesGlycoproteinPyrrolidone carboxylic acid

Molecular function

Cytokine

Cellular component

Secreted

Domain

Signal
Product Datasheet
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