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CD5 Antibody Cocktail

CAT: 0800-V3133SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3133SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-) . Anti-CD5 does not react with granulocytes or monocytes.
CAS Number
9007-83-4
Specifications
ELISA: 1-2 µg/mL (order BSA/azide-free format), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P06127
Host
Mouse
Reactivity
Human, Rat
Immunogen
Human recombinant protein (C5/473) and a peptide from the intracellular region of human CD5 (CD5/54/F6) were used as the immunogens for this CD5 antibody cocktail.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
C5/473 + CD5/54/F6
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CD5 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD5 antibody cocktail is available for research use only.
Storage Conditions
Store the CD5 antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with CD5 antibody (C5/473 + CD5/54/F6)

UniProtKB · P06127

T-cell surface glycoprotein CD5

CD5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06127
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0N0P4, A8K9I3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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