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C-Myc Antibody

CAT: 0800-V3124-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3124-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL (order BSA/azide-free format), Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2 µg/mL
UniProt
P01106
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from the human protein were used as the immunogen for this c-Myc antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MYC699
Applications
ELISA, FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the c-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This c-Myc antibody is available for research use only.
Storage Conditions
Store the c-Myc antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The optimal dilution of the c-Myc antibody for each application should be determined by the researcher.
Location
Nuclear

UniProtKB · P01106

Myc proto-oncogene protein

MYC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01106
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A024R9L7, A0A087WUS5, A8WFE7, H0YBT0, P01107, Q14026
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative initiationAlternative splicingChromosomal rearrangement

Cellular component

ChromosomeCytoplasmNucleus

Disease

Proto-oncogene

Biological process

TranscriptionTranscription regulation

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