Products for Research Use Only

HCAM Antibody

CAT: 0800-V3013-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3013-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a cell surface glycoprotein of 80-95kDa (CD44/HCAM) on lymphocytes, monocytes, and granulocytes. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95kDa or hematopoietic variant (CD44s) . Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44/HCAM immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P16070
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Recombinant human protein was used as the immunogen for the HCAM antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
HCAM/1097
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the HCAM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HCAM antibody is available for research use only.
Storage Conditions
Store the HCAM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface, cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with HCAM antibody (HCAM/1097)

UniProtKB · P16070

CD44 antigen

CD44_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16070
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD44
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A5YRN9, B6EAT9, D3DR12, D3DR13, O95370, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Blood group antigenReceptor

Biological process

Cell adhesion

Cellular component

Cell membraneCell projectionMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Domain

SignalTransmembraneTransmembrane helix