Recombinant Human PPARG protein(His tag)

Recombinant Human PPARG protein(His tag)

• Background: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
• Abbreviation: PPARG
• Synonyms: Nuclear receptor subfamily 1 group C member 3, PPAR-gamma, PPAR-γ
• CAS Number: 9000-83-3
• UniProt: P37231
• Accession Number: P37231
• Host: E. coli
• Origin Species: Human
• Tag: N-His
• Sequence: Pro234-Tyr505
• Field of Research: Epigenetics and Nuclear Signaling,Neuroscience,Stem Cells,Cardiovascular,Metabolism
• Purity: > 80% as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
• Molecular Weight: 20 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.