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VEGF Antibody / VEGFA

CAT: 0800-V2926SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2926SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb recognizes proteins of 19-22kDa (reducing) and 38kDa-44kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF) . It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF) . There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 4-8 µg/mL for 30 min at RT
UniProt
P15692
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant protein was used as the immunogen for the VEGF antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM225
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the VEGF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This VEGF antibody is available for research use only.
Storage Conditions
Store the VEGF antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the VEGF antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 8, for 10-20 min followed by cooling at RT for 20 min.
Location
Cytoplasmic, cell surface and extracellular (secreted)
Image Legend
IHC: Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with VEGF antibody (clone SPM225) .

UniProtKB · P15692

Vascular endothelial growth factor A, long form

VEGFA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15692
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VEGFA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
L-VEGF
EC number
—
Processing
Precursor
Secondary accessions
B5BU86, H0Y2S8, H0Y407, H0Y414, H0Y462, H0Y8N2, H3BLW7, O60720, O75875, Q074Z4, Q16889, Q5UB46, Q6P0P5, Q96KJ0, Q96L82, Q96NW5, Q9H1W8, Q9H1W9, Q9UH58, Q9UL23
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative initiationAlternative promoter usageAlternative splicing

Biological process

AngiogenesisDifferentiation

Cellular component

CytoplasmEndoplasmic reticulumExtracellular matrixGolgi apparatusNucleusSecreted

Molecular function

Developmental proteinGrowth factorHeparin-bindingMitogen

PTM

Disulfide bondGlycoprotein

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