UACA Antibody

• Description :

  UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

• Specifications :

  Western blot: 0.5-1 µg/mL

• UniProt :

  Q9BZF9

• Host :

  Mouse

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant human protein was used as the immunogen for the UACA antibody.

• Clonality :

  Monoclonal

• Isotype :

  IgG1 k

• Clone :

  UACA/1222

• Applications :

  WB

• Purity :

  Protein G affinity chromatography

• Format :

  Purified

• Buffer :

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Reconstitution :

  Store the UACA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations :

  This UACA antibody is available for research use only.

• Storage Conditions :

  Store the UACA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation :

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

• Applications Notes :

  Optimal dilution of the UACA antibody should be determined by the researcher.

• CAS Number :

  9007-83-4

• Location :

  Nuclear membrane

• Image Legend :

  Western blot of A549 cell lysate using UACA antibody (UACA/1222)