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PODXL Antibody

CAT: 0800-V2791-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2791-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Podocalyxin/PODXL is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
O00592
Host
Mouse
Reactivity
Human, Rat
Immunogen
A recombinant protein fragment containing the intracellular, transmembrane, and part of the extracellular domain of human Podocalyxin was used as the immunogen for the PODXL antibody.
Clonality
Monoclonal
Isotype
IgM k
Clone
4F10
Applications
FACS, IF, IHC-P
Purity
PEG precipitation
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PODXL antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PODXL antibody is available for research use only.
Storage Conditions
Store the PODXL antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface and cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human angiosarcoma stained with PODXL antibody (4F10) .

UniProtKB · O00592

Podocalyxin

PODXL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00592
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PODXL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A6NHX8, Q52LZ7, Q53ER6
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneCell projectionMembrane

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

GlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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GTR18081482-01PODXL Antibody

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