Products for Research Use Only
RegisterLogin

Involucrin Antibody

CAT: 0800-V2647-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V2647-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this mAb reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P07476
Host
Mouse
Reactivity
Human
Immunogen
Purified involucrin from human keratinocytes was used as the immunogen for the Involucrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
IVRN/827
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Involucrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Involucrin antibody is available for research use only.
Storage Conditions
Store the Involucrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with Involucrin antibody (clone IVRN/827) .

UniProtKB · P07476

Involucrin

INVO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07476
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IVL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T7P4
Protein keywords

Cellular component

Cytoplasm

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Isopeptide bondLipoprotein

Biological process

Keratinization

Domain

Repeat

Related Products

CatalogName
V5442-20UGRecombinant IVL Antibody / Involucrin
V5442SAF-100UGRecombinant IVL Antibody / Involucrin
V5442-100UGRecombinant IVL Antibody / Involucrin
RQ4624NONO Antibody / p54nrb Antibody
F53954-0.2MLAntibody
F53954-0.05MLAntibody
F53952-0.2MLAntibody
F53952-0.05MLAntibody
V8674-20UGInhibin alpha Antibody / INHA antibody
V8674SAF-100UGInhibin alpha Antibody / INHA antibody

Alternative Products

CatalogName
10R-I148aInvolucrin antibody
GWB-7C3ABDInvolucrin, Antibody

Popular Products