IGF-1 Antibody

• Description:

  This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

• Specifications:

  Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-4 µg/mL, In-vitro neutralization of biological activity of IGF-1 (order BSA/sodium azide-free format)

• UniProt:

  P05019

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Full-length recombinant human IGF1 protein was used as the immunogen for the IGF-1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  IGF1/1020

• Applications:

  FACS, IF, Neutralization

• Purity:

  Protein G affinity chromatography

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Reconstitution:

  Store the IGF-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This IGF-1 antibody is available for research use only.

• Storage Conditions:

  Store the IGF-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

• Applications Notes:

  Optimal dilution of the IGF-1 antibody should be determined by the researcher.

• CAS Number:

  9007-83-4

• Location:

  Cytoplasmic (secreted)