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Granzyme B Antibody

CAT: 0800-V2564-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2564-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'non-self' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.
CAS Number
9007-83-4
Specifications
Flow Cytometry: 0.5-1ug/million cells in 0.1ml, Immunofluorescence: 0.5-1 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT (1)
UniProt
P10144
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment (amino acids 73-187) from the human protein was used as the immunogen for the Granzyme B antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
FACS, IF, WB, IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Granzyme B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Granzyme B antibody is available for research use only.
Storage Conditions
Store the Granzyme B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Granzyme B antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
Location
Cytoplasmic
Image Legend
Western blot analysis of human stomach lysate using Granzyme B antibody. Predicted molecular weight: 29-37 kDa.
Product Datasheet
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