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Granzyme A Antibody

CAT: 0800-R30665Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30665Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are though to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A .
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P12544
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human Granzyme A (DRKVCNDRNHYNFNPV) was used as the immunogen for this Granzyme A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Granzyme A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Granzyme A antibody is available for research use only.
Storage Conditions
After reconstitution, the Granzyme A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Granzyme A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Granzyme A antibody and Lane 1: Jurkat; 2: CEM; 3: Raji cell lysate

UniProtKB · P12544

Granzyme A

GRAA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12544
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GZMA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.78
Processing
Precursor
Secondary accessions
A4PHN1, Q6IB36
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usage

Biological process

Cytolysis

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

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