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CD71 Antibody / Transferrin Receptor

CAT: 0800-V2261CF488-100TSize: 100 TestsDry Ice: NoHazardous: No
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CAT#:0800-V2261CF488-100TSize:100 Tests
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Description
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-3 µg/mL
UniProt
P02786
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this Transferrin receptor / CD71 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
66IG10
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
CF488 Conjugate
Buffer
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD71 antibody at 2-8oC, protected from light.
Limitations
This CD71 antibody is available for research use only.
Storage Conditions
Store the CD71 antibody at 2-8°C, protected from light.
Formulation
500 ul at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD71 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
Flow cytometry testing of K562 cells with AF488 conjugated CD71 antibody (green, clone 66IG10), cells alone (black) and isotype control (gray) .

UniProtKB · P02786

Transferrin receptor protein 1

TFR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02786
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFRC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TR, TfR, TfR1, Trfr
EC number
—
Processing
—
Secondary accessions
D3DXB0, Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variantMalaria

PTM

Disulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Biological process

EndocytosisHost-virus interaction

Molecular function

Host cell receptor for virus entryReceptorTransducer

Domain

Signal-anchorTransmembraneTransmembrane helix
Product Datasheet
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