CD34 Antibody

CAT: 0800-V2067SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V2067SAF-100UGSize:100 µg
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Description
This antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into three main categories, class I, class II and class III. This is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. CD34 antibody labels > 85% of angiosarcoma and Kaposi�s sarcoma, but with a lower specificity.
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
Host
Mouse
Reactivity
Human
Immunogen
A detergent solubilized vesicular suspension prepared from human term placenta was used as the immunogen for this CD34 antibody.
Clonality
Monoclonal
Isotype
IgG1 λ
Clone
QBEnd/10
Applications
FACS, IF, IHC-P
Purity
Protein G purified antibody
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the CD34 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD34 antibody is available for research use only.
Storage Conditions
Store the CD34 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cell surface
Image Legend
IHC testing of human tonsil (10X) stained with CD34 antibody (QBEnd/10) .

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